Light as Therapy for Sleep Disorders and Depression in Older Adults

Authors: Philip D. Sloane, MD, MPH, Mariana Figueiro, PhD, and Lauren Cohen, MA

Proper lighting is necessary for vision and to carry out one’s daily activities. This aspect of light-light for vision – is well known by the general public and health professionals. What is less well appreciated is the large and growing body of scientific literature on light as a therapeutic agent. Indeed, although much has been documented over the past decades about its therapeutic uses, light is rarely prescribed by physicians and other healthcare providers. In part, this is because much is yet to be understood about the optimum characteristics of light affecting our health and well-being. Published research studies have employed a wide range of light sources, quantities, spectra, and delivery schedules, without yielding a consensus as to how to optimally provide this treatment. However, underuse of light as therapy is also due to the fact that light is naturally available, and thus unpatentable, making it unappealing as a research or marketing venue for industries.1

Sleep disorders and depression are extremely common in older persons, and in research trials, light therapy has shown some benefits for treating these disorders. Although drug treatments are available for both conditions, in each case the available drugs are not always effective and carry with them the risk of adverse effects. Therefore, healthcare providers treating older persons might benefit from considering light therapy as an alternative or adjunct therapy for selected patients with sleep disorders or depression. In this article, we review the physiology, scientific evidence, therapeutic uses, and cautions regarding light as a therapeutic agent for these common geriatric conditions, and provide recommendations for clinicians.

Physiology of Light as Therapy
The physiological foundation of light as therapy for sleep-wake cycle disturbances is based on the understanding that living organisms have adapted to the daily rotation of the earth by developing biological rhythms that repeat at approximately 24-hour intervals (ie, circadian rhythms); the most prominent physiological manifestations of these are the sleep-wake cycle and diurnal variations in melatonin secretion, cortisol, and core body temperature. The regulation of melatonin and temperature is controlled by the suprachiasmatic nucleus (SCN) in the hypothalamus of the brain, which fluctuates cyclically but needs an external stimulus to maintain a consistent 24-hour cycle. That key external stimulus is variation in light and darkness over the course of the day and, in particular, exposure to high light levels during the morning hours. These cyclical changes in light levels in turn synchronize the SCN to the 24-hour day, assuring the timing of physiological rhythms, so that we are asleep during nighttime hours and awake during daytime hours.

Impairment of these SCN-mediated circadian rhythms becomes increasingly common with advancing age, diminished health, and Alzheimer’s disease, thereby contributing to the high prevalence of sleep disturbances in these populations.2-4 Older adults have shown depressed melatonin rhythm amplitudes and alterations in the body’s temperature cycle, which may explain the sleep disorders commonly found in these individuals.5 Thus, the mechanism of light therapy for sleep disorders could be via stimulation of the SCN, effectively correcting the timing and/or strengthening the amplitude body’s circadian cycles.

The physiological basis by which light affects mood is less well established. Light therapy is, however, a recognized and consistently demonstrated treatment for seasonal affective disorder (SAD). Although the mechanisms associated with positive effects of light in alleviating SAD symptoms are still unknown, it is believed that the circadian system might be involved, through stimulation of the SCN via the retinohypothalamic tract. The SCN’s postsynaptic fibers release norepinephrine, thus it is logical to hypothesize that alterations in this cycle could affect mood by influencing the serotonergic and/or norepinephrinergic system.6 However, research on melatonin levels in both young and older adults has failed to identify a consistent relationship between either the amount or the timing of melatonin secretion and depression.6-8 Therefore, although the ameliorative effects of light on seasonal depression are largely accepted, the mechanism of action is not well understood.

Clinical Effectiveness of Light Therapy in Older Persons
Over two dozen studies have evaluated the efficacy of light therapy in the treatment of circadian sleep disorders and/or depression (including SAD) in older persons. Many of the studies are small, however, and are limited by their design. In addition, wide protocol variation exists in terms of the treatment applied. For instance, in studies reviewed for this article, the duration of treatment ranged from 30 minutes to 8 hours per day; the light levels from 200 lux to 10,000 lux; the spectrum from polychromatic white light to nearly monochromatic green or blue light; the timing from morning to evening, to all day; and the intervention length from days to weeks. In the following paragraphs, we review these studies and attempt to interpret the overall state of evidence.

Sleep Disorders
A large body of literature substantiates the effectiveness of light as therapy in laboratory settings using young persons as subjects. In general, these studies are conducted to better understand the underlying mechanisms through which light affects the circadian system. Although some laboratory studies have included older adults as subjects, very few studies have evaluated light as therapy for older persons in non-laboratory settings. The available literature on light as a therapy for older adults in community settings is less consistent in terms of efficacy findings, likely due to the shortcomings described above. One Cochrane review examined the effects of light therapy on sleep, behavior, and mood in older adults with dementia.9 Of only five studies that met the reviewers’ inclusion criteria, only three were ultimately reviewed due to inappropriate study methodologies. The three articles that were reviewed did not reveal any systematic benefits of light therapy for individuals with dementia.9 Using less stringent inclusion criteria, we identified 21 published studies evaluating the impact of light therapy on sleep quality and efficiency in older persons.10-30 Many involved small samples; six included ten or fewer participants.12,15,18,19,27,28 The majority (15 studies) specifically targeted persons with dementia,11,12,14-17,19-24,27,28,30 and three used depression as a selection criterion.10,20,21 Overall, 14 identified significant improvement in one or more clinical outcomes,10,12-14,17-19,22-27,30 whereas seven did not.11,15,16,20,21,28,29 Improved outcomes appeared to be associated with the amount of light exposure: of the 19 studies reporting these data, seven of nine (78%) with exposures exceeding 6000 lux-hours had positive results,10,13,17,18,22-24 compared with five of ten (50%) with lower exposure levels.12,14,25-27 In contrast, no pattern of association was noted between clinical improvement and dementia status, depression status, or the timing of light therapy. The latter finding is particularly noteworthy, because much of the literature on circadian rhythms states that the majority of older persons are phase-advanced and would benefit more from evening than morning light; however, this belief is not supported by the results of published clinical studies. In conclusion, the findings on light therapy and sleep in older persons are mixed but, overall, suggest a favorable effect in older persons.

Depression
There is a large body of literature on effectiveness of light therapy on SAD in younger adults, and a modest body of literature supporting its effectiveness in other depressive disorders. A 2004 Cochrane review of randomized controlled trials comparing bright light therapy to inactive placebo treatments found that, among 20 methodologically high-quality studies reviewed, SAD was alleviated to a greater extent when individuals were exposed to bright light versus placebo treatments (standardized mean difference, 0.90; 95% confidence interval [CI], -1.50 to -0.31).31 The effects of light appear to extend beyond SAD: a review of 20 studies of light therapy for non-seasonal depression found that bright light therapy was effective in reducing non-seasonal depressive symptoms, with an average effect size of 0.53 (considered “moderate”) across studies.1 The findings have been more consistently positive in studies of light therapy as an adjunct to pharmaceutical treatment for non-seasonal depression in adults (although not necessarily “older” adults).10,32,33 In one randomized, double-blind, controlled trial, for example, participants received daily dosages of 50 mg of the selective serotonin reuptake inhibitor (SSRI) antidepressant sertraline, combined with either bright light treatment or placebo dim light. Participants in the bright light adjunct group experienced greater reductions in depressive symptoms compared to those in the placebo group (P < 0.05).10,33

We identified seven published studies of the impact of light therapy on depressive symptoms in older persons.20-22,25,34-36 Of these, three reported significant improvement with light therapy,34-36 and four did not.20-22,25 While the small number of studies (and the relatively modest samples in all published studies) renders any conclusions tentative, reported improvement does not appear to be associated with the total amount of light exposure or the timing of the therapy in the diurnal cycle. Of possible importance is the fact that three of the four negative studies specifically selected persons with dementia,20-22 whereas all three of the positive studies studied more general populations;34-36 if valid, this conclusion could be the result of either ineffectiveness or of insensitive measures due to the fact that depression is difficult to diagnose and measure in persons with dementia.

In conclusion, existing studies are inconclusive but suggest that light may have a modest effect on depressive symptoms in older persons, particularly those who do not have dementia. In addition, the strong findings in several studies of bright light as an adjunct to pharmacotherapy, which (although not exclusively conducted in the elderly) included older persons, suggest that this role may be particularly appropriate until further data are available on light as a primary therapeutic agent.10,32,33,37

Dose and Application
In this section, we review what is known about the influence of light levels, duration, timing, and spectrum of light therapy on clinical outcomes, and—although many questions remain—provide tentative therapeutic recommendations. In general, the optimal characteristics of light as therapy differ from those for vision. Table I summarizes optimal lighting characteristics for both vision and therapy.
The light levels required for a therapeutic effect are considerably higher than that needed for vision.38 In general, the recommended minimum light therapy is 2500 lux of white, broadband light at the cornea for a 2-hour exposure or as much as 10,000 lux for a 30-minute exposure. If natural light is used, a rough guideline is that 2500 lux is equivalent to being outside on a cloudy day, and 10,000 lux to being outdoors on a sunny but not excessively bright day (outdoor light levels as high as 100,000 lux have been recorded). The higher the light level provided, the more attention must be given to glare reduction. High light levels can result in discomfort, and thus limit retinal light exposure due to squinting and gaze aversion. Studies conducted in very controlled laboratory conditions showed that much lower light levels (about 100 lux at the cornea of a 4100K fluorescent light) applied for 6.5 hours can phase shift the circadian system of humans.39 However, no studies to date have been able to clearly demonstrate that light levels this low are enough to activate the circadian system outside laboratory conditions. More importantly, light levels used in light therapy for older persons should account for the reduced retinal illuminance due to changes in the aging eye.

Until recently, little was known about the spectral sensitivity of the circadian system, that is, the maximally effective light color; however, a series of studies have shown that blue light (peaking between 440 nm and 460 nm) is maximally effective in suppressing melatonin.40-44 The practical implication of these data is displayed in Table II, which compares the ability of commercial light sources to stimulate the visual and circadian systems.
Although it is well established that timing of exposure is critical in altering circadian rhythms, the optimal timing of light therapy remains controversial. In general, light therapy should be applied in the evening to produce a phase advance, and in the morning to produce a phase delay;43,45,46 however, results contradicting laboratory findings have been reported. Duration of exposure needed to impact the circadian system is greater than that needed to impact the visual system. The visual system will respond in milliseconds, while it might take several minutes to days before one can detect the impact of light on circadian rhythms. Finally, vision requires simultaneous light/dark contrast across the visual field, whereas light therapy appears to require light/dark contrast across time, especially to affect circadian rhythms. Moreover, it appears that light reaching the lower retina is more effective for the circadian system than light reaching the upper retina.
In the absence of consistent findings, the following as a clinical approach should be considered:

•Provide white light sources with bluish tint (ie, 7500K fluorescent light bulb) that provide at least 1000 lux at the eye during daytime hours. If these light levels are considered too high, try to use lower lux blue light delivered via a light box. In this case, the person will have to sit in front of the lights for a certain amount of time daily.
•Provide the therapy at the time that is most convenient for the patient, since consistency is important, especially in influencing circadian rhythms. If the circadian timing of the patient is not known, morning light (after awakening) should be able to at least maintain entrainment, which may be just what the patient needs.
•If convenience is not an issue, ask if the patient tends to be more tired in the morning or in the late afternoon/early evening, and provide the light therapy during that time interval.
•If feasible (eg, by providing high light levels [at least 1000 lux at the cornea] of environmental bluish white light), consider all-daytime (eg, 7:00 AM-8:00 PM) bright light, coupled with dim warm-color light (eg, incandescent light bulbs) at night.

Clinical trials of individualized timing, such as that suggested here, remain to be conducted in older persons.

Available Treatment Modalities
Light boxes are the most common treatment devices available on the market. They are rectangular fixtures that house several light bulbs, usually fluorescent tubes, and that require the user to sit facing them for between half an hour and two hours. In general, light boxes provide a high amount of light (from 2500 lux to 10,000 lux at the cornea). The main drawbacks of such devices are the necessity to remain in one place, and the fact that some users experience discomfort from having to face in the general direction of the bright light (a drawback of all light treatments). Most experts recommend the 10,000-lux box because the recommended duration of exposure is less.

A similar product is the high-intensity desk lamp. If oriented properly in relation to the eyes (ie, at the manufacturer’s recommended distance and in front of the user), a desk lamp can produce up to 10,000-lux exposure at the cornea. As with other light sources, visual discomfort can result; the advantage is that the desk lamp can be less obtrusive for office or home use.
Light visors provide a portable alternative to light boxes and are comprised of a head-mounted light source that resembles a tennis visor. The visor is designed to give people mobility during light sessions and portability for travel; however, it can be cumbersome for some users. Because the light source is close to the eye (and preferentially reaches the more sensitive lower portion of the retina), it requires lower intensities, with a 3000 lux to produce benefits comparable to a 10,000-lux light box.

Until recently, all of the available light boxes, visors, and desk lamps used “full-spectrum” light. More recently, however, products have become available that use a nearly monochromatic light source, the light-emitting diode (LED). Some use blue LEDs, peaking at 470 nm, while others use blue/green LEDs, peaking at approximately 500 nm. Because the peak wavelength of the blue LEDs is close to the maximum sensitivity of the circadian system, much lower light levels can be used, though not all the manufacturers are taking advantage of this feature. Light boxes using blue LEDs typically provide approximately 400 lux at the cornea; light visors using the blue/green LED emit intensities ranging from 500 lux to 12,000 lux.

A low-tech alternative to commercial products would be for an older person to spend 20-30 minutes outdoors daily, preferably at about the same time each morning. Even an overcast day will produce 2500 lux at the cornea, and bright sunshine can produce exposures greater than 10,000 lux at the cornea.
The dawn simulator is marketed primarily for people with SAD; however, it could be useful for people who are phase-delayed (ie, have trouble getting up in the morning). These use incandescent light bulbs and are programmed to gradually increase the light levels in the morning hours, simulating the sunrise. While the evidence of effectiveness is largely anecdotal, and light intensities achieved are often below those of light boxes, lamps, or visors, dawn simulators may have therapeutic value in certain sleep disorders and/or as a supplement to other lighting treatment modalities.

An experimental, not-yet-proven method of applying light therapy is the use of even, therapeutic light intensities throughout an entire room. However, when high levels of ambient lighting are used in facility common areas, the cost can be high and the light levels can be uncomfortable to some individuals; use of skylights and/or monochromatic blue light sources may reduce these problems. Exposure of all individuals rather than targeting affected patients is also a significant drawback of light therapy in public areas; an intriguing alternative would be the design of systems for use in residential areas, such as private rooms in long-term care facilities or the living areas of private homes.

Adverse Effects
One of the advantages of light as therapy is that it appears to be relatively free of serious adverse effects. Theoretically plausible potential risks include retinal damage, the induction of mania and/or agitation, heightened photosensitivity, and general somatic and psychosomatic complaints (headache, nausea, jitteriness, anxiety). The available randomized trials indicate, however, that the prevalence of major adverse effects are virtually nil, and that minor adverse effects occur at similar or only modestly increased rates among users in comparison to matched controls.11,47-53
Because exposure to direct sunlight can lead to cataracts and retinal damage, and both ultraviolet radiation and high levels of short-wavelength light can damage the lens and the retina, concern has been raised about the short- and long-term effects of light therapy on the eye.54 To date, such concerns have only been speculative; trials of up to 10,000 lux have not documented eye damage as a result of light therapy, in part because ultraviolet radiation-blocking filters or coatings are applied to most light fixtures.33,48,55 In spite of negative research findings, many experts recommend, as a precautionary measure, excluding patients with degenerative retinal diseases,34,54,56 as well as those without a lens,54 from light therapy.

Some experts are particularly concerned that blue light exposure may be a hazard, compared to full-spectrum light; however, outdoor exposure to daylight and sunlight are, in general, more likely to be hazardous than short-duration exposure to blue light therapy, and thus the adverse effects of blue light do not seem significant.12,44,57

Although no serious eye damage has been reported as a result of light therapy, a number of transient visual symptoms have been reported in greater frequency among persons exposed to light therapy than among controls. Commonly reported ocular side effects of light therapy include eyestrain,47,53 blurred vision,31 seeing spots,49 glare,49 and eye burning/irritation.31,49 Nearly all studies reported fast remission of symptoms; thus, side effects may only occur early in treatment as part of an adjustment phase. Other, non-visual symptoms have also been reported in some studies of light therapy, including headache,10,31,47,49,58 nausea,49,58 dizziness,47 agitation,31 and jumpiness/jitteriness/anxiety.47,58 These adverse events are reported to be particularly common in studies in which the light source is close to the eyes, such as with head-mounted units like visors.58 In contrast, a recent randomized trial in two long-term care facilities identified no significant increase in the prevalence of seeing spots, problems with glare, eye burning or irritation, eye redness, jitteriness, severe agitation, skin rash on the face or arms, headache, dizziness, or nausea when bright light (2500 lux) was compared to standard light (500 lux).59

Induction of mania has been reported in a few individuals receiving light therapy for treatment of depression.50,60,61 The induced mania is likely a result from effective treatment of a patient with an underlying undiagnosed bipolar disorder, as has been reported with other depression treatments.60 Hypomania, “wiredness,” and agitation have also been reported in a small proportion of persons treated for depression, which should be kept in mind, especially in treating patients with dementia.48,49,53

Suicide has been reported in a few patients with depression not long after initiation of light therapy;47,62 however, the initiation of any effective antidepressant treatment is known to occasionally lead to suicidal actions in a few persons.63 In fact, antidepressant medications have been reported to increase suicidal risk in adults, and SSRIs in particular may put elderly populations at increased risk for suicide in the early stages of treatment.64 Thus, the possibility of suicide should be a caution but not a contraindication to light as therapy for depression.

Recommendations for Clinical Practice
High light levels of bluish white light (at least 1000 lux at the cornea) during morning hours should be considered as a possible therapy for selected older persons with sleep problems and/or depressive symptoms. Particularly appropriate candidates for such treatment would be persons who are at high risk for adverse effects from medications and individuals who rarely go outdoors. In warm climates, half an hour of outdoor daylight exposure each morning would constitute an inexpensive, convenient first-line treatment. When outdoor exposure is impractical, one of the available modalities for indoor light therapy can be prescribed.

Patients with sleep complaints should undergo a thorough medical examination prior to initiation of light therapy. That evaluation should include screening for conditions for which specific therapies are indicated, such as obstructive sleep apnea, medication-related sleep disorders, and alcoholism. Screening for depression is also important in the evaluation of patients with sleep complaints; however, the presence of depression should by no means be a contraindication to light therapy for sleep problems. Treatment for most sleep disorders appears to be best if the light is applied in the morning; however, selected individuals may benefit more from early evening light exposure.

Light appears to have a relatively modest effect as a therapy for depression in older persons. Therefore, except in cases of SAD or of relatively mild symptoms, it should probably be used as an adjunct to other treatments, such as SSRIs and/or psychotherapy. Light therapy may be of particular complementary value due to its rapid onset of action, which has been demonstrated to occur within days rather than the weeks required by medication. Patients should time their exposure to the most convenient time of day; if patients have flexibility, however, morning or mid-day light may be optimal.

Because of the theoretical risk of retinal damage, light therapy should likely be avoided in persons with significant retinal damage (eg, severe macular degeneration) or who have no lens in one or both eyes. Patients initiating light therapy should be cautioned that eye discomfort may result and instructed that, if it is mild, they may continue treatment. They should also be informed that, in some patients, nonspecific symptoms such as headache, dizziness, and jitteriness are sometimes observed, but that these are usually mild and may be transient. Both patients and family members should be cautioned that, although highly unlikely, they should be on the lookout for and report rashes in light-exposed areas, suicidal thoughts, and/or severe agitation or hypomania. Laboratory monitoring is unnecessary, but periodic follow-up visits and re-evaluations should, of course, be a part of the therapeutic plan.

Dr. Sloane and Ms. Cohen report no relevant financial relationships. Dr. Figueiro has received research grants from OSRAM SYLVANIA and Topbulb.com, and reports that General Electric Consumer & Industrial, Philips Lighting, and OSRAM SYLVANIA have provided core support to the operation of the Lighting Research Center.

Acknowledgment
The authors received partial financial support from a Pioneer Award from the Alzheimer’s Association, Award #PIO-04-1004.

References
1. Golden RN, Gaynes BN, Ekstrom RD, et al. The efficacy of light therapy in the treatment of mood disorders: A review and meta-analysis of the evidence. Am J Psychiatry 2005;162(4):656-662.

2. Van Someren EJ, Hagebeuk EE, Lijzenga C, et al. Circadian rest-activity rhythm disturbances in Alzheimer’s disease. Biol Psychiatry 1996;40(4):259-270.

4. Ancoli-Israel S, Poceta JS, Stepnowsky C, et al. Identification and treatment of sleep problems in the elderly. Sleep Med Rev 1997;1(1):3-17.5. Van Someren EJW, Raymann RJEM, Scherder EJA, et al. Circadian and agerelated modulation of thermoreception and temperature regulation: Mechanisms and functional implications. Ageing Res Rev 2002;1(4):721-778.

6. Pandi-Perumal SR, Srinivasan V, Maestroni GJ, et al. Melatonin: Nature’s most versatile biological signal? FEBS J 2006;273:2813-2838.

7. Kripke DF, Youngstedt SD, Rex KM, et al. Melatonin excretion with affect disorders over age 60. Psychiatry Res 2003;118:47-54.

8. Thalen B-E, Kjellman BF, Morkrid L, Wetterberg L. Melatonin in light treatment of patients with seasonal and nonseasonal depression. Acta Psychiatr Scand 1995;92:274-284.

9. Forbes D, Morgan DG, Bangma J, et al. Light therapy for managing sleep, behaviour, and mood disturbances in dementia. Cochrane Database Syst Rev 2004;(2):CD003946.

10. Martiny K. Adjunctive bright light in non-seasonal major depression. Acta Psychiatr Scand Suppl 2004;(425):7-28.

11. Ancoli-Israel S, Martin JL, Kripke DF, et al. Effect of light treatment on sleep and circadian rhythms in demented nursing home residents. J Am Geriatr Soc 2002;50:282-289.

12. Figueiro MG, Eggleston G, Rea MS. Effects of light exposure on behavior of Alzheimer’s patients—A pilot study. The Lighting Research Office of the Electric Power Research Institute. Available at: www.lrc.rpi.edu/programs/lightHealth/pdf/alzheimerStudy.pdf. Accessed January 14, 2008.

13. Alessi CA, Martin JL, Webber AP, et al. Randomized, controlled trial of a nonpharmacological intervention to improve abnormal sleep/wake patterns in nursing home residents. J Am Geriatr Soc 2005;53:803-810.

14. Ancoli-Israel S, Gehrman P, Martin JL, et al. Increased light exposure consolidates sleep and strengthens circadian rhythms in severe Alzheimer’s disease patients. Behav Sleep Med 2003;1(1):22-36.

15. Colenda CC, Cohen W, McCall WV, Rosenquist PB. Phototherapy for patients with Alzheimer’s disease with disturbed sleep patterns: Results of a community-based pilot study. Alzheimer Dis Assoc Disord 1997;11(3):175-178.

16. Dowling GA, Mastick J, Hubbard EM, et al. Effect of timed bright light treatment for rest-activity disruption in institutionalized patients with Alzheimer’s disease. Int J Geriatr Psychiatry 2005;20:738-743.

17. Fetveit A, Skjerve A, Bjorvatn B. Bright light treatment improves sleep in institutionalized elderly-an open trial. Int J Geriatr Psychiatry 2003;18:520-526.

18. Kobayashi R, Fukuda N, Kohsaka M, et al. Effects of bright light at lunchtime on sleep of patients in a geriatric hospital I. Psychiatry Clin Neurosci 2001;55(3):287-289.

19. Koyama E, Matsubara H, Nakano T. Bright light treatment for sleep-wake disturbances in aged individuals with dementia. Psychiatry Clin Neurosci 1999;53:227-229.

20. Loving RT, Kripke DF, Elliot JA, et al. Bright light treatment of depression for older adults. BMC Psychiatry 2005;5:41.

21. Loving RT, Kripke DF, Knickerbocker NC, Grandner MA. Bright green light treatment of depression for older adults. BMC Psychiatry 2005;5:42.

22. Lyketsos CG, Lindell Veiel L, Baker A, Steele C. A randomized, controlled trial of bright light therapy for agitated behaviors in dementia patients residing in long-term care. Int J Geriatr Psychiatry 1999;14:520-525.

23. Mishima K, Hishikawa Y, Okawa M. Randomized, dim light controlled, crossover test of morning bright light therapy for rest-activity rhythm disorders in patients with vascular dementia and dementia of Alzheimer’s type. Chronobiol Int 1998;15(6):647-654.

24. Mishima K, Okawa M, Hishikawa Y, et al. Morning bright light therapy for sleep and behavior disorders in elderly patients with dementia. Acta Psychiatr Scand 1994;89:1-7.

25. Ouslander JG, Connell BR, Bliwise DL, et al. A nonpharmacological intervention to improve sleep in nursing home patients: Results of a controlled clinical trial. J Am Geriatr Soc 2006;54:38-47.

26. Rosenthal NE, Joseph-Vanderpool JR, Levendosky AA, et al. Phase-shifting effects of bright morning light as treatment for delayed sleep phase syndrome. Sleep 1990;13(4):354-361.

27. Satlin A, Volicer L, Ross V, et al. Bright light treatment of behavioral and sleep disturbances in patients with Alzheimer’s disease. Am J Psychiatry 1992;149(8):1028-1032.

28. Skjerve A, Holsten F, Aarsland D, et al. Improvement in behavioral symptoms and advance of activity acrophase after short-term bright light treatment in severe dementia. Psychiatry Clin Neurosci 2004;58:343-347.

29. Suhner AG, Murphy PJ, Campbell SS. Failure of timed bright light exposure to alleviate age-related sleep maintenance insomnia. J Am Geriatr Soc 2002;50:617-623.

30. Van Someren EJ, Kessler A, Mirmiran M, Swaab DF. Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients. Biol Psychiatry 1997;41:955-963.

31. Tuunainen A, Kripke DF, Endo T. Light therapy for non-seasonal depression. Cochrane Database Syst Rev 2004;(2):CD004050.

32. Benedetti F, Colombo C, Pontiggia A, et al. Morning light treatment hastens the antidepressant effect of citalopram: A placebo-controlled trial. J Clin Psychiatry 2003;64(6):648-653.

33. Martiny K, Lunde M, Unden M, et al. Adjunctive bright light in non-seasonal major depression: Results from patient-reported symptom and well-being scales. Acta Psychiatr Scand 2005;111:453-459.

34. Sumaya IC, Rienzi BM, Deegan JF 2nd, Moss DE. Bright light treatment decreases depression in institutionalized older adults: A placebo-controlled crossover study. J Gerontol A Biol Sci Med Sci 2001;56A(6):M356-M360.

35. Tsai YF, Wong TK, Juang YY, Tsai HH. The effects of light therapy on depressed elders. Int J Geriatr Psychiatry 2004;19:545-548.

36. Yamada N, Martin-Iverson MT, Daimon K, et al. Clinical and chronobiological effects of light therapy on nonseasonal affective disorders. Biol Psychiatry 1995;37:866-873.

37. Loving RT, Kripke DF, Shuchter SR. Bright light augments antidepressant effects of medication and wake therapy. Depress Anxiety 2002;16:1-3.

38. Rea MS. Light—Much more than vision. The Lighting Research Office of the Electric Power Research Institute. Available at:www.lrc.rpi.edu/programs/lightHealth/pdf/moreThanVision.pdf. Accessed January 14, 2008.

39. Zeitzer JM, Dijk DJ, Kronauer R, et al. Sensitivity of the human circadian pacemaker to nocturnal light: Melatonin phase resetting and suppression. J Physiol 2000;526(Pt. 3):695-702.

40. Brainard GC, Hanifin JP, Greeson JM, et al. Action spectrum for melatonin regulation in humans: Evidence for a novel circadian photoreceptor. J Neurosci 2001;21(16):6405-6412.

41. Thapan K, Arendt J, Skene DJ. An action spectrum for melatonin suppression: Evidence for a novel non-rod, non-cone photoreceptor system in humans. J Physiol 2001;535(Pt 1):261-267.

42. Wright HR, Lack LC, Kennaway DJ. Differential effects of light wavelength in phase advancing the melatonin rhythm. J Pineal Res 2004;36:140-144.

43. Figueiro MG, Bullough JD, Parsons RH, Rea MS. Preliminary evidence for spectral opponency in the suppression of melatonin by light in humans. Neuroreport 2004;15(2):313-316.

44. Figueiro MG, Rea MS. LEDs: Improving the sleep quality of older adults. Presented at: CIE Midterm Meeting and International Lighting Congress; May 18-21, 2005; Leon, Spain.

45. Lack L, Wright H, Kemp K, Gibbon S. The treatment of early-morning awakening insomnia with two evenings of bright light. Sleep 2005;28(5):616-623.

46. Zeitzer JM, Khalsa SBS, Boivin DB, et al. Temporal dynamics of late-night photic stimulation of the human circadian timing system. Am J Physiol Regul Integr Comp Physiol 2005;289:839-844. Epub 2005 May 12.

47. Genhart MJ, Kelley KA, Coursey RD, et al. Effects of bright light on mood in normal elderly women. Psychiatry Res 1993;47(3):87-97.

48. Labbate LA, Lafer B, Thibault A, Sachs GS. Side effects induced by bright light treatment for Seasonal Affective Disorder. J Clin Psychiatry 1994;55(5):189-191.

49. Kogan AO, Guilford PM. Side effects of short-term 10,000-lux light therapy. Am J Psychiatry 1998;155(2):293-294.

50. Kantor DA, Browne M, Ravindran A, Horn E. Manic-like response to phototherapy. Can J Psychiatry 1991;36(9):697-698.

51. Roberts JE, Remé CE, Dillon J, Terman M. Exposure to bright light and the concurrent use of photosensitizing drugs. N Engl J Med 1992;326:1500-1501.

52. Sloane PD, Noell-Waggoner E, Hickman S, et al. Implementing a lighting intervention in public areas of long-term care facilities: Lessons learned. Alzheimer’s Care Quarterly 2005;6:280-293.

53. Levitt AJ, Joffe RT, Moul DE, et al. Side effects of light therapy in seasonal affective disorder. Am J Psychiatry 1993;150(4):650-652.

54. Remé CE, Terman M. Does light therapy present an ocular hazard? Am J Psychiatry 1992;149(12):1762-1763.

55. Waxler M, James RH, Brainard GC, et al. Retinopathy and bright light therapy. Am J Psychiatry 1992;149:1610-1611.

56. Roberts JE. Hazards of sunlight exposure to the eye. In: Giacomoni PU, ed. Sun Protection in Man. Amsterdam, The Netherlands: Elsevier Science, B.V.; 2001:155-174.

57. Bullough JD. The blue-light hazard: A review. Journal of the Illuminating Engineering Society 2000;29(2):6-14, 141.

58. Terman M, Terman JS. Bright light therapy: Side effects and benefits across the symptom spectrum. J Clin Psychiatry 1999;60(11):799-809.

59. Sloane PD, Zimmerman S, Williams C, et al. High intensity, low glare environmental light (HILGEL) as therapy in Alzheimer’s disease: Results of a clinical trial. Presented at: 58th Annual Conference of the Gerontological Society of America; November 18-22, 2005; Orlando, FL.

60. Chan PK, Lam RW, Perry KF. Mania precipitated by light therapy for patients with SAD. J Clin Psychiatry 1994;55:454.

61. Schwitzer J, Neudorfer C, Blecha H, Fleischhacker WW. Mania as a side effect of phototherapy. Biol Psychiatry 1990;28:532-534.

62. Praschak-Rieder N, Neumeister A, Hesselmann B, et al. Suicidal tendencies as a complication of light therapy for seasonal affective disorder: A report of three cases. J Clin Psychiatry 1997;58:389-392.

63. Food and Drug Administration. Suicidality in adults being treated with antidepressant medications. Food and Drug Administration Public Health Advisory 2005. Available at: www.fda.gov/cder/drug/advisory/SSRI200507.htm. Accessed January 14, 2008.

64. Juurlink DN, Mamdani MM, Kopp A, Redelmeier DA. The risk of suicide with selective serotonin reuptake inhibitors in the elderly. Am J Psychiatry 2006;163(5):813-821.

Light as Therapy for Sleep Disorders and Depression in Older Adults, consultant360.com article, April 2008

Scroll to Top